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Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Andreana, Marco Sentosa, Ryan Erkkilä, Mikael Timo Drexler, Wolfgang Unterhuber, Angelika |
| Copyright Year | 2019 |
| Abstract | Multimodal imaging platforms offer a vast array of tissue information in a single image acquisition by combining complementary imaging techniques. By merging different systems, better tissue characterization can be achieved than is possible by the constituent imaging modalities alone. The combination of optical coherence tomography (OCT) with non-linear optical imaging (NLOI) techniques such as two-photon excited fluorescence (TPEF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) provides access to detailed information of tissue structure and molecular composition in a fast, label-free and non-invasive manner. We introduce a multimodal label-free approach for morpho-molecular imaging and spectroscopy and validate the system in mouse skin demonstrating the potential of the system for colocalized acquisition of OCT and NLOI signals. |
| Starting Page | 997 |
| Ending Page | 1008 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c8pp00410b |
| PubMed reference number | 30882117 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 5 |
| Alternate Webpage(s) | https://pubs.rsc.org/en/content/articlepdf/2019/pp/c8pp00410b |
| Alternate Webpage(s) | https://doi.org/10.1039/c8pp00410b |
| Journal | Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
