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Effect of Testosterone on Proliferation Markers and Apoptosis in Breasts of Ovariectomized Rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oliveira, Jussara Celi Conceição Steiner, Marcelo Luis Theodoro, Thérèse R. Mader, Ana Maria Amaral Antonio Petri, Giuliana Abreu, Luiz Carlos Pinhal, Maria Aparecida Silva Fernandes, César Eduardo Pompei, Luciano De Melo |
| Copyright Year | 2019 |
| Abstract | OBJECTIVE To investigate the action of testosterone (T), isolated or associated with estradiol benzoate (EB), on the proliferation markers and apoptosis of breasts of ovariectomized rats. METHODS A total of 48 castrated female Wistar rats were divided into 6 groups, and each of them were submitted to one of the following treatments for 5 weeks: 1) control; 2) EB 50 mcg/day + T 50 mcg/day; 3) T 50mcg/day; 4) EB 50 mcg + T 300 mcg/day; 5) T 300 mcg/day; and 6) EB 50 mcg/day. After the treatment, the mammary tissue was submitted to a histological analysis and immunoexpression evaluation of proliferation markers (proliferating cell nuclear antigen, PCNA) and apoptosis (caspase-3). RESULTS There was a statistically significant difference among the groups regarding microcalcifications and secretory activity, with higher prevalence in the groups treated with EB. There was no difference among the groups regarding atrophy, but a higher prevalence of atrophy was found in the groups that received T versus those that received EB + T. There was a difference among the groups regarding the PCNA (p = 0.028), with higher expression in the group submitted to EB + T 300 mcg/day. Regarding caspase-3, there was no difference among the groups; however, in the group submitted to EB + T 300 mcg/day, the expression was higher than in the isolated T group. CONCLUSION Isolated T did not have a proliferative effect on the mammary tissue, contrary to EB. Testosterone in combination with EB may or may not decrease the proliferation, depending on the dose of T. |
| Starting Page | 703 |
| Ending Page | 709 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-0039-3399552 |
| PubMed reference number | 31856289 |
| Journal | Medline |
| Volume Number | 41 |
| Issue Number | 12 |
| Alternate Webpage(s) | https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0039-3399552.pdf |
| Journal | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
