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Determination of Endocrine Disrupting Compounds such as Hormones in Environmental Water Samples by HPLC-MS
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2013 |
| Abstract | This paper present the development of a method for etermination of four hormones in water samples, due to their toxicity effects hormones suc h as Estrone (E1), 17 β-Estradiol (E2), 17 α -Estradiol (E3) and 17 α-Ethinylestradiol (EE2), possess endocrine disrupti on potential even at trace concentration levels. Hormones in water samples have been classified as “ emerging pollutants”; these compounds enter water streams through waste water treatment p la s (WWTP) and they can be found in both surface and ground water. A significant femini zation could be observed at a concentration of approximately 1 ng/L reflecting th e strong endocrine disrupting potential of these compounds. As a result of these low concentra tions a suitable analytical methodology is essential for their determination. In the past residues of estrogens in aqueous and so lid environmental samples have been commonly analysed by gas chromatography (GC) equipp ed with mass spectrometer, however the necessary derivatisation steps are not only tim e consuming and laborious but also tedious. This study utilises a sensitive analytical methodol gy for the analysis of these hormones in source and processed water samples at ultra-trace c oncentration levels. Analytes were extracted by traditional solid phase extraction (SP E) and consequently injected into Liquid chromatography coupled to mass spectrometer (HPLC-M S) for analyte determinations. The limits of quantification were 0.20 ng/L for all nalytes, recoveries were 95.6, 93.8, 97.6 and 100.1 % for 17 α Ethinylestradiol, 17 α-Estradiol, 17βEstradiol and Estrone respectively. Treated potable water samples do not contain detect abl levels of hormones, this is due to the stringent Randwater’s treatment process, and endocr ine disruptors are removed during water purification. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.nla.org.za/conferences/proceedings_archive/2013/Manuscripts/Tuesday,%208%20October/T107%20Determination%20of%20Endocrine%20Disrupting%20Compounds%20such%20as%20Hormones%20in%20Environmental%20Water%20Samples%20by%20HPLC-M.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
