Prescription Trends in Schizophrenia and Manic Depressive Psychosis

Content Provider	Semantic Scholar
Author	Sawhney, Vineeta Chopra, Vineet Kapoor, Bianca C. Thappa, Jagdish R. Tandon, Vishal R.
Abstract	From The P.G Deptt. of Pharmacology & Therapeutics and *Department of Psychiatry, Govt Medical College, Jammu (J&K). Correspondence to: Dr.Vineeta Sawhney, Postgraduate Department of Pharmacology & Therapeutics, Government Medical College Jammu. Introduction Schizophrenia and manic depressive psychosis is a chronic mental disorder affecting up to 3-5 in every 1000 people with a life time prevalence of about 1% across all the cultures (1). Numerous antipsychotics, antidepressants and sedatives are available in the market. Use of chlorpromazine (phenothiazine) in schizophrenic patients was discovered through the acute observations made by a French surgeon Laborit in 1947 (2). Since then schizophrenia has been treated with well established antipsychotics which are often referred to as classical or typical antipsychotics (e.g chlorpromazine, haloperidol, fluphenazine, thioridazine, flupenthixol, clopenthixol). These drugs are effective in patients having acute florid positive symptoms. Recent development of atypical neuroleptics causes less incidence of extrapyramidal side effects, effective in treatment of resistant group of schizophrenic patients, effective against both positive & negative symptoms and has better receptor profile (2). However, the major disorder of mood includes the syndrome of major depression & bipolar disorder (manic depressive psychosis). Bipolar disorder is marked by recurrence of severe depression & manic excitement often with psychotic features (3). At present lithium is used as prophylactic drug in MDP. Now a days use of antiepileptics like carbamazepine and valporate have emerged as alternatives to lithium. Terrorism erodes a sense of security and safety at both the individual and community level. Studies have shown that deliberate violence creates longer lasting mental health effects than natural disasters or accidents. (4,5). Jammu and Kashmir has been affected by militancy since more than a decade. Many families have been affected directly or indirectly by its cruel hands irrespective of age, cast, sex or religion. Recently rising number of psychiatric patients recorded in Jammu Psychiatry Hospital associated with Jammu Medical College was the cause of interest to study trends of prescriptions in Psychiatry Hospital. Moreover, hardly any Indian study of prescriptions has looked at this aspect. Hence, the present study was carried out to reveal Abstract The prospective study was carried out by collecting and evaluating prescriptions trends in schizophrenia and manic depressive psychosis in Outpatient in Government Psychiatry Hospital, Jammu. The present study indicated nitrazepam & parkinforte (Trifluperazine + chlorpromazine + Trihexphenidyl ) to be the most preferred drug for treatment of schizophrenia whereas nitrazepam and lithium for manic depressive psychosis. The present study suggests that prescriptions of our hospital are rational and includes drug therapy as per standard treatment guidelines (2002) of WHO.
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