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The long-term prognosis of newly diagnosed epilepsy in Egypt: A retrospective cohort study from an epilepsy center in Greater Cairo
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ashmawi, A. Hosny, Hassan Abdelalim, Ahmed Ali Bianchi, Elisa Beghi, Ettore |
| Copyright Year | 2016 |
| Abstract | PURPOSE To investigate the long-term prognosis and prognostic patterns of epilepsy in a single practice study from a developing country. METHODS Consecutive patients first seen in an epilepsy clinic in Cairo, Egypt between January 1994 and December 2009 with at least 4 years of follow-up were included. Demographic, clinical, EEG and imaging findings at diagnosis were recorded. At follow-up, treatment was adjusted as clinically indicated. The response to the first drug was defined as 6-month seizure remission. Outcome measures included 2-year remission (R) and 2-year sustained remission (SR). Prognostic patterns were early (ER) and late remission (LR), relapsing-remitting (RR) course, worsening course (WC) and no remission. RESULTS Included were 287 patients aged 1-66 years and followed for 2237.0 person-years (mean 7.8 years). 244 (85%) attained 2-year R. The cumulative time dependent probability of R was 86.7% at 10 years. Only the response to the first drug predicted R. 82 (28.6%) attained 2-year SR. The probability of SR was 40.9% at 10 years. Poor treatment response and nocturnal seizures predicted lowered SR. R and SR were inversely correlated to the number of drugs. 208 patients (72.5%) entered ER, 36 (12.5%) entered LR, 138 (48.1%) had RR course. A WC was present in 24 (8.4%), 43 (15.0%) never entered remission. Prognostic patterns varied with neurological examination, MRI findings, pre-treatment seizure frequency, seizure type, number of seizure types, etiology, syndrome and response to first drug. CONCLUSIONS The long-term prognosis of newly diagnosed epilepsy patients from a developing country is in keeping with published reports. |
| Starting Page | 86 |
| Ending Page | 95 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.seizure.2016.07.016 |
| PubMed reference number | 27521898 |
| Journal | Medline |
| Volume Number | 41 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1059131116301224 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1059131116301224 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.seizure.2016.07.016 |
| Journal | Seizure |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
