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Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat
| Content Provider | Semantic Scholar |
|---|---|
| Author | Légrádi, Gábor Hannibal, Jens Lechan, Ronald M. |
| Copyright Year | 1998 |
| Abstract | Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN). In this study, using well-characterized antibodies against PACAP and corticotropin-releasing hormone (CRH), we identified numerous nerve fibers with PACAP-immunoreactivity (ir) closely apposed to CRH neurons in the medial parvocellular subdivision of the rat PVN. Electron microscopy revealed the presence of synapses between PACAP-ir containing terminals and CRH-perikarya and -dendrites. These morphological observations suggest that PACAP may modulate the activation of the hypothalamic-pituitary-adrenal axis. |
| Starting Page | 145 |
| Ending Page | 148 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0304-3940(98)00255-9 |
| PubMed reference number | 9792613 |
| Journal | Medline |
| Volume Number | 246 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394098002559 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394098002559?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0304-3940%2898%2900255-9 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
