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Ferritin levels and their association with regional brain volumes in Tourette's syndrome.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gorman, Daniel A. Zhu, Hongtu Anderson, George M. See Davies, Mark Peterson, Bradley S. |
| Copyright Year | 2006 |
| Abstract | OBJECTIVE A previous small study showed lower serum ferritin levels in subjects with Tourette's syndrome than in healthy subjects. The authors measured peripheral iron indices in a large group of Tourette's syndrome and comparison subjects and explored associations of ferritin levels with regional brain volumes. METHOD Ferritin was measured in 107 children and adults (63 Tourette's syndrome, 44 comparison); serum iron was measured in 73 (41 Tourette's syndrome, 32 comparison). Magnetic resonance imaging scans were used to measure volumes of the basal ganglia and cortical gray matter. RESULTS Ferritin and serum iron were significantly lower in the Tourette's syndrome subjects, although still within the normal range. No association was found between tic severity and either iron index. In the Tourette's syndrome subjects, ferritin did not correlate significantly with caudate volume but did correlate positively with putamen volume. In the comparison subjects, ferritin correlated inversely with caudate volume but did not correlate significantly with putamen volume. Irrespective of diagnosis, ferritin correlated positively with volumes of the sensorimotor, midtemporal, and subgenual cortices. CONCLUSIONS The lower peripheral ferritin and iron levels in persons with Tourette's syndrome are consistent with findings in other movement disorders and suggest that lower iron availability may have a causal role in the pathophysiology of tic disorders. Lower iron stores may contribute to hypoplasia of the caudate and putamen, increasing vulnerability to developing tics or to having more severe tics. Lower iron stores may also contribute to smaller cortical volumes and consequently to reduced inhibitory control of tics. |
| Starting Page | 771 |
| Ending Page | 774 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.feingold.org/Research/PDFstudies/Gorman2006-open.pdf |
| Alternate Webpage(s) | http://www.talkingaboutthescience.com/studies/Gorman2006-open.pdf |
| PubMed reference number | 16816233v1 |
| Volume Number | 163 |
| Issue Number | 7 |
| Journal | The American journal of psychiatry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Basal Ganglia Behavioral tic Ferritin measurement Gilles de la Tourette syndrome Gray Matter Inhibitory Nerve Control Iron measurement Lambert-Eaton Myasthenic Syndrome Mental association Movement Disorders Peripheral Neuropathy Scanning Small Stiff-Person Syndrome Structure of putamen Sturge-Weber Syndrome Tic disorder |
| Content Type | Text |
| Resource Type | Article |
