NDLI: Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899

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Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899

Content Provider	Semantic Scholar
Author	Aoyagi, Azusa Yano, Tatsuya Kozuma, Shiho Takatsu, Toshio
Copyright Year	2007
Abstract	Pleofungins (formerly called F-15078) A, B, C and D, novel depsipeptide antifungal antibiotics, were found in a mycelium extract of the producing fungus, Phoma sp. SANK 13899. The structures of pleofungins A, B, C and D were elucidated mainly by various NMR studies. The absolute configurations of the amino acids and N-methyl amino acids of pleofungin A constituents in the hydrolysate were determined by the application of advanced Marfey's method in combination with gas chromatography/mass spectrometry analysis of their silylation products with N-methyl-N-(tert-butylsilyl)trifluoroacetamide. Two α-hydroxy acid constituents, α-hydroxyisocaproic acid and α-hydroxyisovaleric acid, were isolated from the hydrolysate and their stereochemistries were determined by their specific rotations.
Starting Page	143
Ending Page	152
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1038/ja.2007.14
PubMed reference number	17420565
Journal	Medline
Volume Number	60
Alternate Webpage(s)	http://wxjs.chinayyhg.com/upload/Files/20161023000105381/60_143.pdf
Alternate Webpage(s)	https://doi.org/10.1038/ja.2007.14
Journal	The Journal of Antibiotics
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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