NDLI: The Effect of the Injinhotang Extract on the Hepatocarcinogenesis Induced by N-Nitrosodiethylamine and Carbon Tetrachloride in Rats

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The Effect of the Injinhotang Extract on the Hepatocarcinogenesis Induced by N-Nitrosodiethylamine and Carbon Tetrachloride in Rats

Content Provider	Semantic Scholar
Author	Yoon, Jung Sik Kim, Jeong Sang
Copyright Year	2009
Abstract	In order to examine the effect of Injinhotang extract on the hepatocarcinogenesis induced by N-nitrosodiethyl- amine (NDEA) and carbon tetrachloride (CCl4) in 8 week-old rats. Experimental rats were subdivided into three groups; normal group (Nor), hepatic cancer inducing control group (Con), and control group administered Injinhotang extract 260 mg/kg/day (IJH). The body weight decreased significantly (p<0.05) in the Con compared with the Nor. The body weight of IJH group more increased than Con. Rats intoxicated with NDEA had sig- nificantly (p<0.05) increased levels of serum AST, ALT, LDH, ALP, and AFP. On the contrary, group treated with Injinhotang extract had inhibited levels of serum AST, ALT, LDH, ALP, and AFP. The bcl-2 mRNA ex- pression levels in rat liver were more increased in the IJH than Con, but these levels of c-myc mRNA were more decreased in the IJH than Con. Also, cytoplasmic vacuolizations in the liver of NDEA-administrated rats were inhibited by the treatment of Injinhotang extract. These results suggest that administration of Injinhotang extract suppresses or retards NDEA and CCl4-induced hepatocarcinogenesis in rats.
Starting Page	436
Ending Page	441
Page Count	6
File Format	PDF HTM / HTML
DOI	10.3746/jkfn.2009.38.4.436
Volume Number	38
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/kfn/SPOOBG/2009/v38n4/SPOOBG_2009_v38n4_436.pdf
Alternate Webpage(s)	https://doi.org/10.3746/jkfn.2009.38.4.436
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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