NDLI: Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

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Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

Content Provider	Semantic Scholar
Author	Besson, Morgane Granon, Sylvie Mameli-Engvall, Monica Cloëz-Tayarani, Isabelle Maubourguet, Nicolas Cormier, Anne Cazala, Pierre David, Vincent Changeux, Jean-Pierre Faure, Philippe
Copyright Year	2007
Abstract	Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers opposing processes differentially mediated by beta2- vs. alpha7nAChRs. These data offer previously undescribed insights into the understanding of nicotine addiction and the treatment of several human pathologies by nicotine-like agents chronically acting on beta2- or alpha7nAChRs.
Starting Page	187
Ending Page	190
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/104/19/8155.full.pdf
PubMed reference number	17470777v1
Volume Number	104
Issue Number	19
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Acetylcholine Addictive Behavior Cholinergic Receptors Homeostasis Nicotine Dependence Nicotinic Receptors Pharmacology Precipitating Factors
Content Type	Text
Resource Type	Article

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