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Renal insufficiency and long-term mortality and incidence of myocardial infarction in patients undergoing coronary artery bypass grafting.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Holzmann, Martin J. Hammar, Niklas Ahnve, Staffan Nordqvist, Tobias Pehrsson, Kenneth Ivert, Torbjörn |
| Copyright Year | 2007 |
| Abstract | AIMS To evaluate the impact of renal insufficiency (RI) on long-term mortality and incident myocardial infarction (MI) in patients undergoing coronary artery bypass grafting (CABG). METHODS AND RESULTS All patients (n = 6575) without dialysis-dependent RI undergoing a first isolated CABG during 1980-1995 at the Karolinska hospital who survived 30 days post-operatively were included. Estimated glomerular filtration rate (eGFR) was related to the incidence of MI and all-cause mortality within 5 years. There were 628 deaths and 496 incident MIs during follow-up. After multivariable adjustment, patients with mild (eGFR 60-90 mL/min), moderate (eGFR 30-60 mL/min), and severe (eGFR <30 mL/min) RI had an increased mortality within 5 years post-CABG; hazard ratio (HR) 1.2 [95% confidence interval (CI) 1.0-1.6], HR 1.8 (95% CI 1.3-2.4), and HR 5.2 (95% CI 3.1-8.6), respectively, compared with patients with normal renal function (eGFR >90 mL/min). In patients with moderate and severe RI, there was an increased incidence of MI; HR 1.5 (95% CI 1.1-2.1) and HR 3.5 (95% CI 1.8-6.8), respectively. There were no gender differences. CONCLUSION Already mild RI predicts late all-cause mortality after coronary artery bypass grafting (CABG), and moderate and severe RI is associated with an increased long-term incidence of MI post-CABG. |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/eurheartj/ehl508 |
| PubMed reference number | 17303587 |
| Journal | Medline |
| Volume Number | 28 |
| Issue Number | 7 |
| Alternate Webpage(s) | https://watermark.silverchair.com/ehl508.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAk0wggJJBgkqhkiG9w0BBwagggI6MIICNgIBADCCAi8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMVRAYK_OzH7VP3EI3AgEQgIICAOxPd3muBFv8nVjP0WEM1u4SVV_bCpqwDlW1vVHL85OWAdMJOTcN7ikJsmPmejG_xfCgw5rCgR0RIW0djWT3aRS8aVCokmvv0yScg-eOVgVKDNcbhm1Pd3fuvNok1XJ9nlZwLLDOiCAWuDDL1UmI2qC8s2A-9a-MhmQMeIwHTcLsrfkntXk9m8rnF6m25YhEIFagn1YY2gv6a1Onmdr5B8iq6SLS7xQGrdRxwbSQipLciYcTN85N6ism8F5AOryS7I4zZFIwRxB-L8fpPd4Ys6Y01GcwjoTl-8O_p0nqef1xXcyi0duRkFQ6N98v1DIfRHlCbfjM2wKIaySB24VXcstM0gIEmbK6RIdEqPIDStRjfLjzmXbGage9miTZzTlsDKc6jcKqkSeq6jeZXoSXIxw2YJY4k6RMz_81YaR4V2sPx_ZxsqIio58YCfR84WwgUox6qJoY8Lh2dQEbOkhV2e8qEP3GH1ZNv6fzVbMi6gh_-A2FVgdyGx5PQnAlII5xJoL1PvZDPOdoECT1e5s7GNN4A2Q_BGXPgIR9u1qeODqtrW__OOLKcc0Bhc2yCcs-LOnWr3I33zV__Rf_3HHev-KlnE_bivs-PPxS2ufs7P56YL-LzlIEJST2fdOyBZkA6YKhLA0CiP_Uv7ThCXU5ytazfH97Wkk99PDhCpeLjTp_ |
| Alternate Webpage(s) | https://doi.org/10.1093/eurheartj%2Fehl508 |
| Journal | European heart journal |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
