SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 1-(6-NITRO-2H-BENZO[b][1,4]THIAZINE-3(4H)-YLIDENE)HYDRAZINE-1,1-DIOXIDE DERIVATIVES

Content Provider	Semantic Scholar
Author	Maheshwari, Monika Goyal, Anju
Copyright Year	2016
Abstract	Objective: The objective of this research was to synthesize and evaluate anti-microbial properties of 1-(6-nitro-2 H -benzo[ b ][1,4]thiazine-3(4 H )-ylidene)hydrazine-1,1-dioxide derivatives. Methods: These new compounds were synthesized by reaction of 2 H -benzo[b][1,4]thiazin-3(4 H )-one with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method. Results: The FTIR, 1 HNMR, 13 CNMR and Mass studies confirms the synthesis of some new 1-(6-nitro-2 H -benzo[ b ][1,4]thiazine-3(4 H )-ylidene) hydrazine-1,1-dioxide derivatives. Compound 5f showed potent antimicrobial activity whereas compounds 5c and 5e showed moderate antimicrobial activity. Conclusion: Result obtained in this research work clearly indicated that the compound 5f having methyl at 2 position and nitro groups at 2′ and 4′ position showed the most potent antimicrobial activity.
Starting Page	178
Ending Page	182
Page Count	5
File Format	PDF HTM / HTML
DOI	10.22159/ijpps.2016v8i10.13673
Alternate Webpage(s)	https://innovareacademics.in/journals/index.php/ijpps/article/download/13673/7318
Alternate Webpage(s)	https://doi.org/10.22159/ijpps.2016v8i10.13673
Volume Number	8
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article