NDLI: Substance P-immunoreactive nerve fibres in the anterior segment of the rabbit eye

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Substance P-immunoreactive nerve fibres in the anterior segment of the rabbit eye

Content Provider	Semantic Scholar
Author	Tornqvist, K. Mandahl, Agneta Leander, Stefan Lorén, Ingemar Håkanson, Rolf Sundler, Frank
Copyright Year	2004
Abstract	SummarySubstance P-immunoreactive nerve terminals were found in several locations in the anterior segment of the rabbit eye. In the iris they occurred in the sphincter muscle and were randomly distributed in the iris stroma with some fibres running close to the dilator muscle. In the ciliary body these immunoreactive elements were few and occurred within bundles of nerve fibres, while in the ciliary processes they were more numerous with a predominantly subepithelial location. Blood vessels in the anterior uvea were often surrounded by substance P-immunoreactive fibres. No substance P-fibres were found in the cornea, while the sclera contained very few such elements.Using conventional in vitro techniques it was found that the sphincter pupillae muscle of the iris responded to electrical stimulation with a contraction that was resistant to cholinergic and adrenergic blockade, but was inhibited by the neuronal blocker tetrodotoxin. This indicates the existence of a non-cholinergic, non-adrenergic neuronal mediator of the contractile response. Exogenously applied substance P produced a long-lasting contraction of the spincter muscle, an observation compatible with the view that substance P is the noncholinergic, non-adrenergic neurotransmitter involved.
Starting Page	467
Ending Page	477
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1007/BF00213848
PubMed reference number	6174236
Journal	Medline
Volume Number	222
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF00213848
Alternate Webpage(s)	https://doi.org/10.1007/BF00213848
Journal	Cell and Tissue Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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