BDNF-Induced Release of Endogenous Cannabinoids at Inhibitory and Excitatory Synapses

Content Provider	Semantic Scholar
Author	Selvam, Rajamani
Copyright Year	2018
Abstract	Endocannabinoids (eCBs) are important mediators of synaptic plasticity, acting as retrograde messengers because they are released on demand from postsynaptic sites and activate presynaptic type I cannabinoid (CB1) receptors to suppress neurotransmitter release at both excitatory and inhibitory synapses. Similarly, brain derived neurotrophic factor (BDNF) is also a potent neuromodulator of synaptic transmission. The effect of BDNF on synaptic transmission is mediated by tropomyosin receptor kinase B (trkB) receptors. Both CB1 and trkB receptors are highly expressed at synapses throughout the neocortex and hippocampus. There is a growing evidence of cross talk between eCB and BDNF signaling. In particular, studies in our lab have shown that BDNF can trigger the release of endogenous endocannabinoids via phospholipase C signaling at inhibitory synapses in somatosensory cortex. It is not known whether BDNF-induced eCB release also occurs at excitatory synapses and in regions other than the neocortex. In the present studies, we examined a potential crosstalk between BDNF and eCB release at excitatory synapses in neocortex and inhibitory synapses in the hippocampus.
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Alternate Webpage(s)	https://opencommons.uconn.edu/cgi/viewcontent.cgi?article=8247&context=dissertations
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article