Genetics and pathophysiology of arterial stiffness.

Content Provider	Semantic Scholar
Author	Lacolley, Patrick Challande, Pascal Osborne-Pellegrin, Mary J. Régnault, Véronique
Copyright Year	2008
Abstract	Arterial stiffness is a cardiovascular risk factor that is independent of arterial pressure. Clinically, carotid-femoral pulse wave velocity (PWV) is the gold-standard parameter of arterial stiffness. Recent genetic studies have revealed specific genes that contribute to arterial stiffening. Here we review the recent findings on genome-wide linkage analyses and candidate gene polymorphism association studies. We also focus on the latest advances in the identification of gene variants affecting PWV using high density array single nucleotide polymorphism technology in a recent genome-wide association (GWA) study. Linkage and polymorphism studies revealed a first group of genes affecting the renin-angiotensin-aldosterone system, elastic fibre structural components, metalloproteinases, and the NO pathway. A second group of genes, identified by polymorphism association studies and possibly involved in the pathophysiology of arterial stiffness, includes beta-adrenergic receptors, endothelin receptors, and inflammatory molecules. The last group of genes, identified by GWA studies and unrelated to currently suspected mechanisms of arterial stiffness, may target transcriptional pathways controlling gene expression, differentiation of vascular smooth muscle cells, apoptosis of endothelial cells, or the immune response within the vascular wall.
Starting Page	7
Ending Page	16
Page Count	10
File Format	PDF HTM / HTML
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PubMed reference number	19098299v1
Alternate Webpage(s)	https://doi.org/10.1093/cvr/cvn353
DOI	10.1093/cvr/cvn353
Journal	Cardiovascular research
Volume Number	81
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic Receptor Aldosterone Angiotensins Arterial Occlusive Diseases Arterial Stiffness Contribution Endothelial Cells Endothelin Receptor FAS protein, human Gene Expression Leukemia, B-Cell Ligands Mental association Metalloproteases Myocytes, Smooth Muscle Nitroprusside Nucleotides Population Parameter Pulse Wave Velocity Pulse wave velocity:Vel:Pt:Arterial system:Qn Single Nucleotide Polymorphism Smooth muscle (tissue) TRANSCRIPTION FACTOR Transcription, Genetic beta-adrenergic receptor drug development genetic linkage
Content Type	Text
Resource Type	Article