NDLI: Ontogeny of calcitonin gene-related peptide and calcitonin in the rat thyroid

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Ontogeny of calcitonin gene-related peptide and calcitonin in the rat thyroid

Content Provider	Semantic Scholar
Author	Nitta, K. Kito, Suzie Kubota, Yukio Girgis, S. I. Hillyard, C. Macintyre, I. Inagaki, Shinobu
Copyright Year	2004
Abstract	SummaryIn this immunohistochemical study, the ontogenic development of calcitonin-gene-related peptide (CGRP) in the rat thyroid was investigated and compared with that of calcitonin using the indirect-immunofluorescence method. Parafollicular cells with immunoreactivity to both CGRP and calcitonin first appeared at an early stage of gestation (days 17 and 18) in the central portion of the thyroid. Cells immunoreactive to CGRP and calcitonin had became numerous by gestational day 22. After postnatal day 7, CGRP- and calcitonin-immunoreactive (CIR) cells increased rapidly both in number and in the intensity of their fluorescence. In 14- to 90-day old rats, many intensely immunoreactive cells were distributed in the central portion of the thyroid. The cells immunoreactive to CGRP and to calcitonin had an almost identical ontogenic appearance. In 14-day-old and adult rats, C-IR cells also exhibited CGRP immunostaining, suggesting that these cells simultaneously produce and store CGRP during ontogeny.
Starting Page	139
Ending Page	143
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1007/BF00499824
PubMed reference number	3519539
Journal	Medline
Volume Number	84
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF00499824
Alternate Webpage(s)	https://doi.org/10.1007/BF00499824
Journal	Histochemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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