Loading...
Please wait, while we are loading the content...
The Value of Technetium-99m Labeled Alpha-Melanocyte-Stimulating Hormone (99mTc-α-MSH) in Diagnosis of Primary and Metastatic Lesions of Malignant Melanoma
| Content Provider | Semantic Scholar |
|---|---|
| Author | Farzanefar, Saeed Etemadi, Rahman Shirkhoda, Mohammad Mahmoodzadeh, Habibollah Erfani, Mostafa Fallahi, Babak Abbasi, Mehrshad Ayati, Narjess Hassanzadeh-Rad, Arman Eftekhari, Mohammad Beiki, Davood |
| Copyright Year | 2018 |
| Abstract | Objectives Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes over expressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic value of 99mTc-α-MSH imaging in malignant melanoma. Methods Twenty-one patients (13 men) with pathologically confirmed malignant melanoma with or without metastatic distribution were included in this study. 740-1110 MBq 99mTc-α-MSH was injected and whole body scans were performed 20, 120 and 240 minutes post injection and were assessed both qualitatively and semi-quantitatively using target (T) to background (BG) ratio. Results The T/BG ratio for the primary tumor bed was 2.51±2.26, 2.56±2.48 and 1.92±1.79 minutes in the whole body scans 20, 120 and 240 minutes post injection, respectively. The sensitivity, specificity, negative and positive predictive values were 75%, 80%, 50% and 92% for primary lesion and 25%, 100%, 68% and 100% for distant metastasis, respectively. Conclusion 99mTc-α-MSH is a newly introduced agent for diagnosis of tumoral lesions in malignant melanoma. Our study showed a high sensitivity with this modality in primary lesions as well as lymph node involvements. However the detection rate was not high in distant metastasis. The preliminary results are promising especially as a new complementary imaging method in management of malignant melanoma. |
| Starting Page | 155 |
| Ending Page | 160 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.22038/aojnmb.2018.30101.1204 |
| Alternate Webpage(s) | http://aojnmb.mums.ac.ir/article_10721_2847c09e8a4a7d8b21ec0ed642ce117b.pdf |
| Alternate Webpage(s) | https://www.tums.ac.ir/1397/04/24/2018-AOJNMB-MSH.pdf-beikidav-2018-07-15-09-46.pdf |
| PubMed reference number | 29998149 |
| Alternate Webpage(s) | https://doi.org/10.22038/aojnmb.2018.30101.1204 |
| Journal | Medline |
| Volume Number | 6 |
| Journal | Asia Oceania journal of nuclear medicine & biology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
