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Localization of myoinhibitory peptide immunoreactivity in Manduca sexta and Bombyx mori, with indications that the peptide has a role in molting and ecdysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Davis, Norman T. Blackburn, Michael B. Golubeva, Elena G. Hildebrand, John G. |
| Copyright Year | 2003 |
| Abstract | For normal development of Manduca sexta larvae, the ecdysteroid titer must drop following its sudden rise at the start of the molting cycle; this sudden decline in titer may be due to myoinhibitory peptide I (MIP I), which has an inhibitory effect on the release of ecdysone by the prothoracic glands of Bombyx mori in vitro. Using an antiserum to MIP, we have demonstrated secretion of an MIP-like peptide by the epiproctodeal glands of Manduca sexta, which are located on each proctodeal nerve, just anterior to the rectum. These MIP-immunoreactive glands are also present in B. mori. In fourth-instar larvae of M. sexta, the epiproctodeal glands show a distinct cycle of synthesis and sudden release of MIP that coincides with the time of the rapid decline in ecdysteroid titer. The function of the epiproctodeal glands appears to be the timely release of MIP during the molting cycle, so as to inhibit the prothoracic glands and thus to facilitate the sudden decline in ecdysteroid titer. In addition, we have found that MIP immunoreactivity is co-localized with that of crustacean cardioactive peptide (CCAP) in the 704 interneurons; these peptides appear to be co-released at the time of ecdysis. It is known that CCAP can initiate the ecdysis motor program; our results suggest that MIP may also be involved in activating ecdysis behavior. |
| Starting Page | 8 |
| Ending Page | 12 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ars.usda.gov/ARSUserFiles/10300/Davis_etal-JEB2003.pdf |
| PubMed reference number | 12654884v1 |
| Volume Number | 206 |
| Part | 9 |
| Journal | The Journal of experimental biology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bombyx Citric Acid Cycle Ecdysone Ecdysteroids Gland Immune Sera Interneurons Larva Macrophage Inflammatory Proteins Manduca Nesiritide REM Sleep Behavior Disorder Rectum Subphylum Crustacea Titer crustacean cardioactive peptide hyperglycemic hormone precursor, crustacean molting cycle |
| Content Type | Text |
| Resource Type | Article |
