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Complete response to azacitidine priming and nab-paclitaxel in non-Hodgkin lymphoma resistant to biochemotherapy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bowen, Randy Christopher Hahn, Andrew W. Butler, Thomas Wayne Khong, Hung T. |
| Copyright Year | 2017 |
| Abstract | The standard of care for first-line therapy in diffuse large B-cell lymphoma (DLBCL) is the rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) regimen. For patients who fail to respond, have an incomplete response or relapse, numerous effective options exists besides salvage cisplatin-based regimen and autologous stem cell therapy. Even with this approach, the outcome remains very poor for this group of patients. The present case illustrates a 55-year-old woman diagnosed with DLBCL, who experienced an early incomplete response, later progression during treatment with the R-CHOP regimen. The patient received salvage therapy with rituximab, cisplatin and gemcitabine, again with an incomplete response. The patient declined consideration for stem cell therapy. Her disease progressed and she enrolled in the present phase I trial using azacitadine priming and nanoalbumin-bound (nab)-paclitaxel. After three cycles, follow-up positron emission tomography/computed tomography revealed a complete response for the first time since her initial diagnosis and the patient has remained disease-free for >6 years. Azacitadine and nab-paclitaxel combination appeared to be an effective regimen for the treatment of this patient with refractory DLBCL. |
| Starting Page | 122 |
| Ending Page | 124 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/mco/6/1/122/download |
| PubMed reference number | 28123744v1 |
| Alternate Webpage(s) | https://doi.org/10.3892/mco.2016.1090 |
| DOI | 10.3892/mco.2016.1090 |
| Journal | Molecular and clinical oncology |
| Volume Number | 6 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Azacitidine B-Cell Lymphomas CHOP protocol-cyclophosphamide/doxorubicin/prednisone/vincristine Cell Therapy Cisplatin Cyclophosphamide Diffuse Large B-Cell Lymphoma Doxorubicin Leukemia, B-Cell Lymphoma, Non-Hodgkin PET/CT scan Paclitaxel Patients Positron-Emission Tomography Positrons Prednisone Priming Exercise Stem cells Vincristine X-Ray Computed Tomography cyclophosphamide/doxorubicin/prednisone/rituximab/vincristine gemcitabine rituximab |
| Content Type | Text |
| Resource Type | Article |
