Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer.

Content Provider	Semantic Scholar
Author	Touillaud, Marina Pillow, Patricia C. Jakovljevic, Jelena Bondy, Melissa L. Singletary, Sonja E. Li, Dong-Hui Chang, Shine
Copyright Year	2005
Abstract	Although many dietary studies have focused on breast cancer risk, few have examined dietary influence on tumor characteristics such as estrogen receptor (ER) status. Because phytoestrogens may modulate hormone levels and ER expression, we analyzed ER status and phytoestrogen intake in a case-case study of 124 premenopausal breast cancer patients. We assessed intake with a food-frequency questionnaire and obtained ER status from medical records. Rather than focusing on risk, we evaluated whether low intakes were more strongly associated with ER-negative tumors than with ER-positive disease. In logistic regression adjusting for potential confounders, threefold greater risks of ER-negative tumors relative to ER-positive tumors were associated with low intake of the isoflavones genistein (odds ratio, OR=3.50; 95% confidence interval, CI=1.43-8.58) and daidzein (OR=3.10; 95% CI=1.31-7.30). Low intake of the flavonoid kaempferol (OR=0.36; 95% CI=0.16-0.83), the trace element boron (OR=0.33; 95% CI=0.13-0.83), and the phytosterol beta-sitosterol (OR=0.42; 95% CI=0.18-0.98) were associated with decreased risk of ER-negative tumors relative to ER-positive disease. Other phytoestrogens were not significantly associated with ER status. Thus, in premenopausal patients, some phytoestrogens may affect breast carcinogenesis by influencing ER status. Such findings suggest new directions for mechanistic research on dietary factors in breast carcinogenesis that may have relevance for prevention and clinical treatment.
Starting Page	75
Ending Page	80
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.encognitive.com/files/Effect%20of%20Dietary%20Intake%20of%20Phytoestrogens%20on%20Estrogen%20Receptor%20Status%20in%20Premenopausal%20Women%20With%20Breast%20Cancer.pdf
PubMed reference number	15860438v1
Volume Number	51
Issue Number	2
Journal	Nutrition and cancer
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic beta-Agonists Carcinogenesis Confidence Intervals Dietary Boron Estrogen Receptor Status - Clinical Trial Eligibility Criteria Estrogen Receptors Estrogens Flavonoids Genistein Isoflavones Mammary Neoplasms Patients Phytoestrogens Phytosterols Sitosterols Status Epilepticus Trace Elements beta Sitosterol cancer risk daidzein estrogen receptor alpha, human flavonoid 3'-hydroxylase activity kaempferol
Content Type	Text
Resource Type	Article