NDLI: Epidemiological features of pertussis resurgence based on community populations with high vaccination coverage in China.

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Epidemiological features of pertussis resurgence based on community populations with high vaccination coverage in China.

Content Provider	Semantic Scholar
Author	Huang, H. T. Zhu, Tiehong Gao, Cun-Yi Gao, Zheng-Qin Liu, Yong Ding, Ya-Xing Sun, Jimin Guo, Liru Liu, Peidong Chen, Derong Wang, Lan Lan Wu, Shuangsheng Zhang, Yan
Copyright Year	2015
Abstract	Active symptom surveillance was applied to three selected communities ( 160,147 persons) in Tianjin from 2010 to 2012. We examined 1089 individuals showing pertussis-like symptoms, of which 1022 nasopharyngeal specimens were tested for pertussis by polymerase chain reaction and 802 sera for anti-pertussis toxin antibodies. Of the total cases tested, 113 were confirmed, and their demographic, clinical, and vaccination-related data were collected. The annual incidence was 23.52 cases/100,000 persons among communities, which was 16.22 times that obtained via hospital reports for the same period (P < 0.001). The actual incidence in the 15-69 years age group was most significantly underestimated by hospitals, given that it was 43.08 times that of the reported hospital rate. Among the cases aged <15 years, 84.5% were individuals who had been fully vaccinated. The misdiagnosis rate was as high as 94.69%, and only 5.31% of the confirmed pertussis cases were properly diagnosed as pertussis at their first medical visit. Pertussis incidence in China has been severely underestimated and this was in part due to a high misdiagnosis rate. Adolescents and adults have become new high-risk populations. Future work should focus on reinforcing immunization programmes, especially among adolescents and adults.
File Format	PDF HTM / HTML
DOI	10.1017/S095026881400260X
PubMed reference number	25286969
Journal	Medline
Volume Number	143
Issue Number	9
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/A4BE7CA1DAEF7C582C10A8A57A320029/S095026881400260Xa.pdf/epidemiological_features_of_pertussis_resurgence_based_on_community_populations_with_high_vaccination_coverage_in_china.pdf
Alternate Webpage(s)	https://doi.org/10.1017/S095026881400260X
Journal	Epidemiology and infection
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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