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Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapses

Content Provider	Semantic Scholar
Author	Milner, A. J. Cummings, Damian M. Spencer, Jonathan P. Murphy, K. P.
Copyright Year	2004
Abstract	Low-frequency stimulation (LFS) is used to induce long-term depression (LTD) and depotentiation at rodent CA3-CA1 hippocampal synapses. The relationship between the efficacy of LFS induction and postnatal age remains to be clearly defined in rat and had not been studied in mouse. The data presented here show that in acute mouse hippocampal slices LFS-induced LTD and depotentiation at CA3-CA1 synapses are: synapse specific; NMDA receptor-dependent; and metabotropic glutamate (mGlu) receptor type I/II independent. Furthermore LFS-induced LTD is highly age-dependent whilst long-term potentiation (LTP) and depotentiation are not. In slices from very young mice (P6-9) LFS induced a robust and stable LTD (-31.1 +/- 5.9%, n = 8, P < 0.01) of CA1 field excitatory post-synaptic potentials (fEPSPs), measured 55-60 min after conditioning. LFS also induced LTD in slices from mice aged P10-13 and P14-17 (-16.0 +/- 3.0%, n = 35, P < 0.001 and -17.9 +/- 5.5%, n = 12, P < 0.01, respectively). However, LTD was not expressed in slices from animals aged P18-21 ( -7.0 +/- 4.1%, n = 16, P > 0.05) or older.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.neulet.2004.04.056
PubMed reference number	15308285
Journal	Medline
Volume Number	367
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394004005087
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394004005087?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.neulet.2004.04.056
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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