Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.

Content Provider	Semantic Scholar
Author	Shimizu, Noriko Ikehara, Yuzuru Inada, Ken Nakanishi, Hirokuni Tsukamoto, Tetsuya Nozaki, Koji Kaminishi, Michio Kuramoto, Shu Sugiyama, Atsushi Katsuyama, Tsutomu Tatematsu, Masae
Copyright Year	2000
Abstract	To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N-nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.
File Format	PDF HTM / HTML
PubMed reference number	10749114
Journal	Medline
Volume Number	60
Issue Number	6
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/60/6/1512.full.pdf
Journal	Cancer research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article