NDLI: Effects of light scattering on optical-resolution photoacoustic microscopy.

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Effects of light scattering on optical-resolution photoacoustic microscopy.

Content Provider	Semantic Scholar
Author	Liu, Yan Zhang, Chi Wang, Lihong V.
Copyright Year	2012
Abstract	The imaging depth of ballistic optical imaging technologies is limited by light scattering. To study the effects of scattering on optical-resolution photoacoustic microscopy (OR-PAM), the signals were divided into target and background signals. A method to simulate the point spread function (PSF) of the PAM system considering both optical illumination and acoustic detection was proposed, then the PSF was used to calculate the contribution of each class of signal at different depths of the focal plane (zf). How image contrast is degraded when there is a uniformly absorbing background as well as when there are small targets densely packed in the acoustic resolution cell were studied. By using the hyperboloid-focusing-based Monte Carlo method, optical focusing into a scattering medium was simulated. It was found that the lateral resolution provided by optical focusing is degraded by only 14% when zf=1.1 transport mean free path (l t'), compared with the case of no scattering. When zf=1.7 lt', the fluence at 50 μm radial distance away from the focal point is 93% of that at the focal point, which shows optical focusing is very weak at this depth. The method to simulate the PSF of PAM can be used in the future to optimize parameters so as to improve the system performance.
Starting Page	126014
Ending Page	126014
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://oilab.seas.wustl.edu/epub/2012%5CLiuY_2012_JBO_v17_126014.pdf
Alternate Webpage(s)	http://authors.library.caltech.edu/69517/1/JBO_17_12_126014.pdf
PubMed reference number	23232794v1
Alternate Webpage(s)	https://doi.org/10.1117/1.JBO.17.12.126014
DOI	10.1117/1.JBO.17.12.126014
Journal	Journal of biomedical optics
Volume Number	17
Issue Number	12
Language	English
Access Restriction	Open
Subject Keyword	CREBZF gene Class Excitation Imaging Technology Magnetic Resonance Imaging Monte Carlo Method PAM gene Pack unit Photoacoustic Spectroscopy Potassium aggravated myotonia Sodium Transducers Ultrasonics (sound)
Content Type	Text
Resource Type	Article

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