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Promoting Precision Addiction Management (PAM) to Combat the Global Opioid Crisis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Blum, Kenneth Modestino, Edward J. Neary, Jennifer Gondré-Lewis, Marjorie C. Siwicki, David Moran, Mark L. Hauser, Mary J. Braverman, Eric R. Baron, David A. Steinberg, Bruce D. Laughlin, Thomas P. Mc Badgaiyan, Rajendra D. |
| Copyright Year | 2018 |
| Abstract | It is universally agreed that dopamine is a major neurotransmitter in terms of reward dependence, however, there remains controversy regarding how to modulate its role clinically to treat and prevent relapse for both substance and non-substance-related addictive behaviors. It is also agreed by most that there is a need to provide early genetic identification possibly through a novel researched technology referred to Genetic Addiction Risk Score(GARS).™ The existing FDA-approved medications promote blocking dopamine, however, we argue that a more prudent paradigm shift should be biphasic-short-term blockade and long-term upregulation, enhancing functional connectivity of brain reward. It is critical to understand that the real phenotype is not any specific drug or non -drug addictive behavior, but instead is Reward Deficiency Syndrome (RDS). Thus the true phenotype of all addictive behaviors is indeed RDS. Finally, we are suggesting that one way to combat the current out of control Opioid /Alcohol crisis worldwide is to seriously reconsider treating RDS by simply supplying powerful narcotic agents (e.g. Buprenorphine). This type of treatment will only keep people addicted. A more reasonable solution involving genetic testing, urine drug screens using Comprehensive Analysis of Reported Drugs (CARD) and dopamine homeostasis we call " Precision Addiction Management" ™ seems parsonomiuos. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://biomedres.us/pdfs/BJSTR.MS.ID.000738.pdf |
| PubMed reference number | 30370423v1 |
| Alternate Webpage(s) | https://doi.org/10.26717/BJSTR.2018.02.000738 |
| DOI | 10.26717/bjstr.2018.02.000738 |
| Journal | Biomedical journal of scientific & technical research |
| Volume Number | 2 |
| Issue Number | 2 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Addictive Behavior Buprenorphine Dopamine Drug Dependence Genetic screening method Narcotics Neurotransmitters REM Sleep Behavior Disorder addict |
| Content Type | Text |
| Resource Type | Article |
