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Deletions fusing the hisG and hisD genes in Salmonella typhimurium.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ino, Ikuko Hartman, Philip E. Hartman, Zlata Yourno, Joseph |
| Copyright Year | 1975 |
| Abstract | Frameshift mutation hisD497 occurs in the operator-proximal portion of the Salmonella typhimurium gene coding for the dimeric protein, L-histidinol dehydrogenase (HDH). Rare revertants of hisD497 are deletions fusing the hisD gene to the adjacent preceding structural gene, hisG (adenosine 5'-triphosphate-PR transferase). HDH purified from one revertant, hisGD4908, contains subunits of approximately normal molecular weight but with no clearly demonstrable unique amino-terminal sequence. We propose that a combined inactive G-D polypeptide is synthesized and then cleaved at a number of closely juxtaposed sites by endoproteolytic activity. At least some of the resulting fragments then participate in formation of active HDH dimers. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/jb.123.3.1254-1264.1975 |
| PubMed reference number | 1099075 |
| Journal | Medline |
| Volume Number | 123 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://jb.asm.org/content/123/3/1254.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1128/jb.123.3.1254-1264.1975 |
| Journal | Journal of bacteriology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
