Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study.

Content Provider	Semantic Scholar
Author	Verwoert, Germaine C. Mattace-Raso, Francesco Umberto Salvatore Hofman, Albert Heeringa, Jan Stricker, Bruno C. Breteler, Monique M. B. Witteman, Jacqueline C. M.
Copyright Year	2008
Abstract	OBJECTIVES To determine the prognostic role of orthostatic hypotension for cardiovascular disease (CVD) and all-cause mortality in elderly people. DESIGN Prospective study. SETTING Community based. PARTICIPANTS Five thousand sixty-four subjects from the Rotterdam study aged 55 and older. MEASUREMENTS Orthostatic hypotension was measured using a Dinamap automatic blood pressure recorder. Orthostatic hypotension is defined as a decline in systolic blood pressure of 20 mmHg or more or a decline in diastolic blood pressure of 10 mmHg or more from supine to standing position at any of three measurements taken 1, 2, and 3 minutes after standing. RESULTS At baseline, 901 subjects had orthostatic hypotension. During follow-up, 668 subjects had coronary heart disease (CHD) (mean follow-up 6.0 +/- 3.5 years), and 1,835 subjects died (mean follow-up period 7.8 +/- 3.8 years). Orthostatic hypotension increased the risk of CHD (hazard ratio (HR)=1.31, 95% confidence interval (CI)=1.08-1.57) and all-cause mortality (HR=1.22, 95% CI=1.09-1.36), in models adjusted for age and sex. The risk was slightly lower after additional adjustment for cardiovascular risk factors. In analyses stratified for age, the HRs for all-cause mortality were 1.80 (95% CI 1.25-2.60), 1.13 (0.89-1.42), and 1.27 (95% CI=1.11-1.44), in the first, second, and third tertile of age, respectively. CONCLUSION Orthostatic hypotension increases the risk of CHD and all-cause mortality in elderly people. The risk of CVD and mortality is strongest in younger and very old subjects.
Starting Page	904
Ending Page	907
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://repub.eur.nl/pub/14708/2008120300255.pdf
PubMed reference number	18795982v1
Alternate Webpage(s)	https://doi.org/10.1111/j.1532-5415.2008.01946.x
DOI	10.1111/j.1532-5415.2008.01946.x
Journal	Journal of the American Geriatrics Society
Volume Number	56
Issue Number	10
Language	English
Access Restriction	Open
Subject Keyword	Blood Pressure Cardiovascular Diseases Cessation of life Choline Dehydrogenase, Mitochondrial Confidence Intervals Coronary heart disease Diastole Heart Diseases Shy-Drager Syndrome Sixty torr
Content Type	Text
Resource Type	Article