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The placenta in pre-eclampsia : association of histology with umbilical artery Doppler velocimetry
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gunasena, Asanka Dmcs Jayasundara Salgado, Sujatha Senadera Wijesinghe Brgdnk, Biyagama |
| Copyright Year | 2017 |
| Abstract | Hypertensive disorders are common during pregnancy requiring close antenatal care. Hypertension in pregnancy is defined as systolic blood pressure 140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart after 20weeks of gestation in a woman with a previously normal blood pressure. Pre-eclampsia (PE) is traditionally defined as new hypertension presenting after 20weeks of gestation with significant proteinuria (≥300mg/dl in 24-hour urine collection).1 Worldwide, pre-eclampsia affects 5-10% of pregnancies and it is a leading cause of maternal morbidity, mortality, fetal growth restriction (FGR), and prematurity.2 The aetiology of PE is still unknown, although an excessive maternal systemic inflammatory response and an imbalance between circulating angiogenic and anti-angiogenic factors have been described.3 The placenta has long been recognized as the necessary component for the genesis of preeclampsia. A common pathological feature of preeclampsia is the failure of the maternal spiral arteries supplying the placenta to undergo the physiological adaptations of normal pregnancy to facilitate adequate placental perfusion.4 This theory of placental hypoperfusion is supported by clinical, pathological and experimental findings.5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://medcraveonline.com/MOJWH/MOJWH-04-00092.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 24-hour clock Abruptio Placentae Acclimatization Adaptation, Physiological Adenoma, Villous Angiogenic Process Basement membrane Congenital Abnormality Diastole Eclampsia Fetal Mortality Statistics GENESIS Hypertensive disease Knot (unit) Morbidity - disease rate PENK wt Allele Placenta Pre-Eclampsia Pregnancy Prenatal care Spiral model Structure of umbilical artery Tissue membrane Umbilicus (Anatomy) hypoperfusion nervous system disorder |
| Content Type | Text |
| Resource Type | Article |
