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Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nilsson-Ohman, Jenny Fredrikson, Gunilla Nordin Nilsson-Berglund, Lisa M. Gustavsson, Carin Bengtsson, Eva Smith, Maj-Lis Agardh, Elisabet Jovinge, Stefan Gómez, M. Fabricio Nilsson, Jan |
| Copyright Year | 2009 |
| Abstract | OBJECTIVE Vascular inflammation is a key feature of both micro- and macrovascular complications in diabetes. Several lines of evidence have implicated the cytokine tumor necrosis factor (TNF) alpha as an important mediator of inflammation in diabetes. In the present study we evaluated the role of TNF alpha in streptozotocin (STZ)-induced diabetes on vascular inflammation in C57BL/6 wild-type and apoE-/- mice. METHODS AND RESULTS Diabetes increased the expression of vascular cell adhesion molecule (VCAM)-1 in cerebral arteries 150 m in diameter as well as the macrophage accumulation in aortic root atherosclerotic plaques in apoE-/- mice. A more pronounced vascular inflammatory response was observed in diabetic TNF alpha-deficient apoE-/- mice. These mice were also characterized by increased accumulation of IgG and IgM autoantibodies in atherosclerotic lesions. Diabetes also increased VCAM-1 expression and plaque formation in apoE-competent TNF alpha -/- mice, whereas no such effects were observed in C57BL/6 wild-type mice. CONCLUSIONS The present findings suggest that TNF alpha does not mediate diabetic-induced vascular inflammation in mice and reveal an unexpected protective role for TNF alpha. These effects are partly attributable to a direct antiinflammatory role of TNF alpha, but may also reflect a defective development of the immune system in these mice. |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/ATVBAHA.109.193862 |
| PubMed reference number | 19755528 |
| Journal | Medline |
| Volume Number | 29 |
| Issue Number | 10 |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/29/10/1465.full.pdf |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/29/10/1465.full.pdf?download=true |
| Alternate Webpage(s) | https://doi.org/10.1161/ATVBAHA.109.193862 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
