Does the 1H-NMR plasma metabolome reflect the host-tumor interactions in human breast cancer?

Content Provider	Semantic Scholar
Author	Richard, Vincent Conotte, Raphaël Mayné, David Crous Colet, J. M.
Copyright Year	2017
Abstract	Breast cancer (BC) is the most common diagnosed cancer and the leading cause of cancer death in women worldwide. There is an obvious need for a better understanding of BC biology. Alterations in the serum metabolome of BC patients have been identified but their clinical significance remains elusive. We evaluated by 1H-Nuclear Magnetic Resonance (1H-NMR) spectroscopy, filtered plasma metabolome of 50 early (EBC) and 15 metastatic BC (MBC) patients. Using Principal Component Analysis, Partial Least-Squares Discriminant Analysis and Hierarchical Clustering we show that plasma levels of glucose, lactate, pyruvate, alanine, leucine, isoleucine, glutamate, glutamine, valine, lysine, glycine, threonine, tyrosine, phenylalanine, acetate, acetoacetate, β-hydroxy-butyrate, urea, creatine and creatinine are modulated across patients clusters. In particular lactate levels are inversely correlated with the tumor size in the EBC cohort (Pearson correlation r = -0.309; p = 0.044). We suggest that, in BC patients, tumor cells could induce modulation of the whole patient's metabolism even at early stages. If confirmed in a lager study these observations could be of clinical importance.
Starting Page	49915
Ending Page	49930
Page Count	16
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://docnum.umons.ac.be/Access/WebOpenAccess/GetDocument.aspx?Filename=oncotarget-08-49915.pdf&GuidTicket=80a68f97-dafd-48cd-8362-e7d54236f4f5
PubMed reference number	28611296
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.18307
DOI	10.18632/oncotarget.18307
Journal	Oncotarget
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Acetate Acetoacetates Alanine Butyrates Creatine Creatinine Glucose Glutamic Acid Glutamine Glycine Isoleucine Lactic acid Leucine Lysine Mammary Neoplasms Metabolome Patients Phenylalanine Pyruvates Threonine Tyrosine Urea Valine lager mecarzole negative regulation of skeletal muscle acetylcholine-gated channel clustering
Content Type	Text
Resource Type	Article