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Minocycline add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Randomized double-blind placebo-controlled study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Khodaie-Ardakani, Mohammad-Reza Mirshafiee, Omid Farokhnia, Mehdi Tajdini Akhondzadeh, Shahin |
| Copyright Year | 2014 |
| Abstract | The objective of this study was to assess the efficacy and tolerability of minocycline add-on to risperidone in treatment of negative symptoms of patients with chronic schizophrenia. In a randomized double-blind placebo-controlled study, 40 patients with chronic schizophrenia who were stabilized on risperidone for a minimum duration of eight weeks were recruited. The patients were randomly assigned to minocycline (titrated up to 200 mg/day) or placebo in addition to risperidone (maximum dose of 6 mg/day) for eight weeks. Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale, and Extrapyramidal Syndrome Rating Scale were used. Thirty-eight patients completed the study. Significant time × treatment interaction for negative [F(2.254,85.638)=59.046, P<0.001] general psychopathology [F(1.703,64.700)=6.819, P=0.001], and positive subscales [F(1.655,62.878)=5.193, P=0.012] as well as total PANSS scores [F(1.677,63.720)=28.420, P<0.001] were observed. The strongest predictors for change in negative symptoms were the treatment group (β=-0.94, t=-10.59, P<0.001) followed by the change in PANSS positive subscale (β=-0.185, t=-2.075, P=0.045). Side effect profiles of the two treatment regimens were not significantly different. Minocycline seems to be an efficacious and tolerable short-term add-on to risperidone for treatment of negative and general psychopathology symptoms of schizophrenia. |
| Starting Page | 540 |
| Ending Page | 546 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.psychres.2013.12.051 |
| PubMed reference number | 24480077 |
| Journal | Medline |
| Volume Number | 215 |
| Alternate Webpage(s) | http://tarjomefa.com/wp-content/uploads/2018/04/8935-English-TarjomeFa.pdf |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0165178114000067 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0165178114000067?dgcid=api_sd_search-api-endpoint |
| Journal | Psychiatry Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
