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Test-Retest and Interreader Reproducibility of Semiautomated Atlas-Based Analysis of Diffusion Tensor Imaging Data in Acute Cervical Spine Trauma in Adult Patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Peterson, David J. Rutman, Aaron M. Hippe, Daniel S. Jarvik, Jeffrey G. Chokshi, Falgun H. Reyes, M. R. Bombardier, C. H. Mossa-Basha, Mahmud |
| Copyright Year | 2017 |
| Abstract | BACKGROUND AND PURPOSE DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts. Regional and white matter tract volume, fractional anisotropy, and mean diffusivity values were calculated. Two readers performed the nonautomated steps to evaluate interreader reproducibility. The coefficient of variation and intraclass correlation coefficient were used to assess test-retest and interreader reproducibility. RESULTS Of 42 patients, 30 had useable data. Test-retest reproducibility of fractional anisotropy was high for white matter as a whole (coefficient of variation, 3.8%; intraclass correlation coefficient, 0.93). Test-retest coefficient-of-variation ranged from 8.0%-18.2% and intraclass correlation coefficients from 0.47-0.80 across individual white matter tracts. Mean diffusivity metrics also had high test-retest reproducibility (white matter: coefficient-of-variation, 5.6%; intraclass correlation coefficient, 0.86) with coefficients of variation from 11.6%-18.3% and intraclass correlation coefficients from 0.57-0.74 across individual tracts, with better agreement for larger tracts. The coefficients of variation of fractional anisotropy and mean diffusivity both had significant negative relationships with white matter volume (26%-27% decrease for each doubling of white matter volume, P < .01). CONCLUSIONS DTI spinal cord segmentation is reproducible in the setting of acute spine trauma, specifically for larger white matter tracts and total white or gray matter. |
| Starting Page | 2015 |
| Ending Page | 2020 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ajnr.org/content/ajnr/early/2017/08/17/ajnr.A5334.full.pdf |
| Alternate Webpage(s) | http://www.ajnr.org/content/ajnr/38/10/2015.full.pdf |
| PubMed reference number | 28818826v1 |
| Alternate Webpage(s) | https://doi.org/10.3174/ajnr.A5334 |
| DOI | 10.3174/ajnr.a5334 |
| Journal | AJNR. American journal of neuroradiology |
| Volume Number | 38 |
| Issue Number | 10 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anisotropy Biological Markers CDISC SDTM Respiratory Test Name Terminology Cervical Plexus Block Cervical segment of spinal cord Cervical spine Coefficient Crew Resource Management, Healthcare Diffusion Tensor Imaging Doubling Eichsfeld type congenital muscular dystrophy Gray Matter Greater Independent Medical Evaluation Large Manuscripts Neck Patients Spinal Cord Injuries Spinal Cord Neoplasms White matter Wounds and Injuries algorithm benefit biologic segmentation funding grant |
| Content Type | Text |
| Resource Type | Article |
