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The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Albensi, B. C. |
| Copyright Year | 2007 |
| Abstract | A recent search on PubMed for the phrase NMDA receptor results in 2,190 hits on this topic for review articles and 20,100 hits for experimental papers. This is a direct reflection of the intensiveness, significance, and complexity associated with the research on this key receptor protein over the last several decades. In this review, we briefly describe the NMDA receptor structure, discuss the role of NMDA receptors in modulating synaptic plasticity and excitotoxicity, explore age-dependent changes in NMDA receptor functioning, and survey interesting NMDA receptor blockers. Given the huge existing literature on the subject, an exhaustive review has not been endeavored. Instead, an attempt was made to point out those studies that have been instrumental in the field or that are of special interest. |
| Starting Page | 999 |
| Ending Page | 1012 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.amwa.org/global_engine/download_custom.asp?blnIsPublic=2&fileid=f4abf18e-4662-4915-ac29-9edb6130d7d4.pdf&filename=Albensi+NMDA+Curr+Pharm+Design+(proofs+)+2007.pdf |
| PubMed reference number | 18045168v1 |
| Volume Number | 13 |
| Issue Number | 31 |
| Journal | Current pharmaceutical design |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Accident and Emergency department Alzheimer's Disease Binding Sites Calcium Calmodulin Drug Delivery Systems In Vitro [Publication Type] Ion Channel Iontophoresis Long-Term Potentiation Memantine Mental association Molecular Biology N-Methyl-D-Aspartate Receptors N-Methylaspartate Neuronal Plasticity Paper Phosphoric Monoester Hydrolases Synaptic Transmission |
| Content Type | Text |
| Resource Type | Article |
