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Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801
| Content Provider | Semantic Scholar |
|---|---|
| Author | Robinson, Gilbert B. |
| Copyright Year | 1991 |
| Abstract | The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment continued for the first 10 days of kindling. MK-801 depressed the growth of the afterdischarge duration and suppressed development of behavioral seizures. MK-801 did not block kindling-induced potentiation of either the perforant path-dentate granule cell population spike or excitatory postsynaptic potential. Random impulse train stimulation and non-linear systems analytic techniques were used to examine kindling-induced potentiation of presumed GABAergic recurrent inhibitory circuits. Both the magnitude and duration of kindling-induced response inhibition, to the second of each pair of impulses within the train, were reduced in rabbits pretreated with MK-801. These results suggest that MK-801 differentially affects kindling-induced potentiation of excitatory and inhibitory circuits within the rabbit hippocampal dentate gyrus. |
| Starting Page | 26 |
| Ending Page | 33 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(91)91182-Z |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/000689939191182Z |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/000689939191182Z?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 1799870 |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2891%2991182-Z |
| Journal | Medline |
| Volume Number | 562 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
