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An in Silico Evaluation of Coccinia Grandis Fruits against Alzheimer's Disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shalini, Gupta M. Ravikumar, P. R. Jeyam, Muthusamy |
| Copyright Year | 2014 |
| Abstract | The aim of the present study is to find the effectiveness of reported phytocompou nds from Coccinia grandis fruit s against Alzheimer's disease. Acetylcholinesterase is an important target in the treatment of Alzheimer's disease and it was taken as a receptor for this study. The reported phytocompounds w ere taken as ligand molecul e s and t he 3D structure of h uman a cetylcholinesterase w as retrieved from PDB database. The 3D structure of synthetic drug and reported phytocompounds were obtained from Pub Chem database. Docking studies were performed using Glide (a Schrodinger module) . From the results , it wa s observed that the phytocompounds β - Sitosterol ( - 8.70 Kcal/mol) , Pectin ( - 7.82 Kcal/mol) , Retinol ( - 7.24 Kcal/mol) and Taraxerone ( - 6.40 Kcal/mol) had better glide score than the synthetic drug r ivastigmine ( - 5.6 Kcal/mol ). Hence, it is suggested that intake of Coccinia grandis fruits can be used to reduce the severity and progress of Alzheimer's disease . |
| Starting Page | 328 |
| Ending Page | 332 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.7897/2277-4572.034166 |
| Volume Number | 3 |
| Alternate Webpage(s) | http://www.jpsionline.com/admin/php/uploads/356_pdf.pdf |
| Alternate Webpage(s) | https://doi.org/10.7897/2277-4572.034166 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
