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Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell.

Content Provider	Semantic Scholar
Author	Ohtsubo, Hideki Ichiki, Toshihiro Miyazaki, Ryohei Inanaga, Keita Imayama, Ikuyo Hashiguchi, Yasuko Sadoshima, Junichi Sunagawa, Kenji
Copyright Year	2007
Abstract	OBJECTIVE The role of inducible cAMP early repressor (ICER), a transcriptional repressor, in the vascular remodeling process has not been determined. We examined whether ICER affects growth of vascular smooth muscle cells (VSMCs). METHODS AND RESULTS Semi-quantitative RT-PCR and Western blot analysis showed that expression of ICER was increased in beraprost (a prostaglandin I2 analogue)-stimulated VSMCs in a time- and dose-dependent manner. The induction of ICER was inhibited by pretreatment with H89, a protein kinase A (PKA) inhibitor, suggesting that PKA mediates the induction of ICER expression. Beraprost suppressed platelet-derived growth factor-induced thymidine incorporation in VSMCs, which was reversed by transfection of short interfering RNA for ICER, not by scramble RNA. Overexpression of ICER by an adenovirus vector attenuated neointimal formation (intima/media ratio) by 50% compared with overexpression of LacZ. The number of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling-positive cells was increased and the number of Ki-67-positive cells was decreased in ICER-transduced artery. CONCLUSION These results suggest that ICER induces apoptosis and inhibits proliferation of VSMCs, and plays a critical role in beraprost-mediated suppression of VSMC proliferation. ICER may be an important endogenous inhibitor of vascular proliferation.
File Format	PDF HTM / HTML
DOI	10.1161/ATVBAHA.107.145011
PubMed reference number	17463330
Journal	Medline
Volume Number	27
Issue Number	7
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/27/7/1549.full.pdf
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/early/2007/04/26/ATVBAHA.107.145011.full.pdf
Alternate Webpage(s)	http://atvb.ahajournals.org/content/27/7/1549.full.pdf
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/early/2007/04/26/ATVBAHA.107.145011.full.pdf?download=true
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/27/7/1549.full.pdf?download=true
Alternate Webpage(s)	https://doi.org/10.1161/ATVBAHA.107.145011
Journal	Arteriosclerosis, thrombosis, and vascular biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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