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Variable ventilation induces endogenous surfactant release in normal guinea pigs.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arold, Stephen P. Suki, Béla Alencar, Adriano M. Lutchen, Kenneth R. Ingenito, Edward P. |
| Copyright Year | 2003 |
| Abstract | Variable or noisy ventilation, which includes random breath-to-breath variations in tidal volume (Vt) and frequency, has been shown to consistently improve blood oxygenation during mechanical ventilation in various models of acute lung injury. To further understand the effects of variable ventilation on lung physiology and biology, we mechanically ventilated 11 normal guinea pigs for 3 h using constant-Vt ventilation (n = 6) or variable ventilation (n = 5). After 3 h of ventilation, each animal underwent whole lung lavage for determination of alveolar surfactant content and composition, while protein content was assayed as a possible marker of injury. Another group of animals underwent whole lung lavage in the absence of mechanical ventilation to serve as an unventilated control group (n = 5). Although lung mechanics did not vary significantly between groups, we found that variable ventilation improved oxygenation, increased surfactant levels nearly twofold, and attenuated alveolar protein content compared with animals ventilated with constant Vt. These data demonstrate that random variations in Vt promote endogenous release of biochemically intact surfactant, which improves alveolar stability, apparently reducing lung injury. |
| Starting Page | 1698 |
| Ending Page | 1701 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajplung.physiology.org/content/ajplung/285/2/L370.full.pdf |
| Alternate Webpage(s) | http://www.bu.edu/lungs/publication%20pdfs/fulltext7.pdf |
| PubMed reference number | 12851212v1 |
| Volume Number | 285 |
| Issue Number | 2 |
| Journal | American journal of physiology. Lung cellular and molecular physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Lung Injury Alveolar ventilation function Bronchoalveolar Lavage Cavia Cell Respiration Irrigation Mechanical ventilation Mechanics Pulmonary Surfactants Structure of parenchyma of lung Tritium physiological aspects |
| Content Type | Text |
| Resource Type | Article |
