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Spectrophotometric Simultaneous Determination of Amlodipine Besylate and Bisoprolol Fumarate in Combined Tablet Dosage Form by Dual Wavelength and Absorbance Corrected Method
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ganesh, C. Nilesh, B. Shelar Kodre, Siddhi Arekar, Priyanka Ashish, Aboti |
| Copyright Year | 2017 |
| Abstract | Two methods for the simultaneous determination of Amlodipine Besylate (AMLO) and Bisoprolol Fumarate (BISO) in combined tablet dosage form by UV spectrophotometry have been developed. These methods are dual wavelength (method A) and absorption corrected (method B). From a solvent effect studies and the spectral behaviors of AMLO and BISO, methanol was selected as solvent. Beer's law was obeyed in the concentration range of 10-30 μg/ml for AMLO and 5-15 μg/ml for BISO, respectively. In methanol AMLO and BISO shown λmax values 230 nm, 223.02 nm and 271 nm, 360 nm respectively. In method A two wavelengths were selected for each drug in a way so that the difference in absorbance is zero for another drug. Wavelengths selected for method B for estimation of AMLO was 234.69 nm; similarly wavelength selected for estimation of BISO was 232.59 nm. Both the methods were applied for formulation analysis and assay result were found in the range of 98.27-99.87%. These methods were validated with respect to linearity, accuracy, precision and robustness as per ICH analytical method validation guidelines. The recovery by proposed methods was found in the range of 98.81-100.94 for both the analytes. The linear, accurate, precise and robust methods have been developed for the simultaneous estimation of AMLO & BISO in combined dosage form. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ijpr.in/Data/Archives/2017/jan/0707201601.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
