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Plasma beta carotene in Alzheimer's disease. Association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), beta-amyloid 1-42 (Abeta42) and total Tau.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stuerenburg, Hans Joerg Ganzer, Stefanie Mueller-Thomsen, Tomas |
| Copyright Year | 2005 |
| Abstract | We studied the plasma beta carotene concentrations in 40 Alzheimer's disease patients and the association with cerebrospinal fluid beta-amyloid 1-40, (Abeta40), cerebrospinal fluid beta-amyloid 1-42 (Abeta42) and cerebrospinal fluid total Tau. We found that patients with plasma beta carotene levels below the 25th percentile had 55% reduced ratios of Abeta40/Tau and 51% reduced ratios of Abeta 40/Abeta 42 compared with patients in the highest quartile. Mean Tau concentrations in the lowest quartile of plasma beta-carotene levels were 74% higher compared with the highest quartile of plasma beta-carotene levels. Thus, we could demonstrate an statistically significant association between beta carotene levels in plasma and neurochemical markers in the cerebrospinal fluid of Alzheimer's disease patients. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 16380679 |
| Journal | Medline |
| Volume Number | 26 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://www.nel.edu/26-2005_6_pdf/NEL260605A33_Stuerenburg.pdf |
| Journal | Neuro endocrinology letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
