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Short-term synaptic plasticity in the dentate gyrus of primates
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tamura, Ryoi Nishida, Hiroshi Eifuku, Satoshi Nagao, Kaoru Watanabe, Yukio |
| Copyright Year | 2011 |
| Abstract | s / Neuroscience Research 71S (2011) e108–e415 e183 P2-p18 Neurons in the central part of dorsal telencephalon (Dc) in zebrafish encode the long-term memory of active avoidance paradigm Tazu Aoki 1 , Ryo Aoki 1, Masakazu Agetsuma 1, Masae Kinoshita 1, Hidenori Aizawa 2, Masako Yamazaki 1, Hitoshi Okamoto 1 1 Brain Science Institut, RIKEN, Wako, Japan 2 Tokyo Medial and Dental University, Tokyo, Japan Recent studies on comparative neuroanatomy and analysis of gene expressions in developing central nervous system suggest that teleostean fish telencephalon may contain counterpart regions for mammalian telencephalic structures which have been demonstrated to be critical for learning and memory. The medial and lateral subregions of the dorsal part of teleostean telencephalon (named as Dm and Dl, respectively) are thought to correspond to the amygdala and hippocampus respectively by developmental gene expression studies and functional studies in goldfish. Although the developmental study suggests the possibility that the central subregion of the dorsal telencephalon (Dc) may be the equivalent structure for mammalian isocortex, this remains unclear. Recently, using calcium imaging of the telencephalon of adult zebrafish trained by active avoidance paradigm, we have identified the neural activity specifically observed in this Dc region when fish is recalling the long-term memory. We then made the ablation experiment of this Dc region to see whether the long-term memory recalling is affected or not. The average trial number required for reaching at the learning criteria has doubled in Dc ablated fish. Moreover, 20% of Dc ablated fish have never reached at the learning criteria. These results suggest strongly that the Dc region of zebrafish telencephalon may store long-term form of memory as does the mammalian cortex. doi:10.1016/j.neures.2011.07.788 P2-p19 Neuron–glia interaction via Drosophila CAM Klingon modulates Repo-mediated glial gene expression required for long-term memory formation Motomi Matsuno 1 , Minoru Saitoe 1,2 1 Tokyo Metropolitan Institute of Medical Science 2 Department of Biological Sciences, Tokyo Metropolitan University, Japan Although glial cells have been believed to function in maintenance of nervous system, recent studies suggest that they are also implicated in synapse formation and plasticity through neuron–glia interaction. However, their contribution to the long-lasting memory is not clear. Previously we found that training-dependent increase in Klingon (Klg), a member of the Drosophila immunoglobulin superfamily of a CAM, is required for long-term memory (LTM) formation. We demonstrate here that Klg protein was localized at the junctures between neuron and glia, and suggest that a training-dependent increase in Klg-mediated neuron–glia interaction is required to form LTM. LTM formation requires new gene expression. We show here that expression of Repo, Drosophila glial-transcription factor was increased upon LTM induction, and Repo-dependent gene expression was physiologically required for LTM formation. Furthermore, acute silencing of klg expression abolished the LTM induced increase in Repo. These results suggest that Klg-mediated neuron–glia interaction induces Repo-dependent glial-gene expression required for LTM formation. Research fund: KAKENHI 21700425. doi:10.1016/j.neures.2011.07.789 P2-p20 Appetitive olfactory learning and associative longterm memory in the nematode Caenorhabditis elegans Saori Nishijima , Ichiro Maruyama Information Processing Biology Unit, Okinawa Institute of Science and Technology C. elegans is an excellent model organism for the study of learning and memory at cellular and molecular levels because of the relative simplicity of the nervous system. Here we developed a paradigm for the study of associative learning and memory by classical (Pavlovian) conditioning of worms with nonanol, as a conditioned stimulus (CS), and potassium chloride (KCl) as an unconditioned stimulus (US). Before the conditioning, worms avoided nonanol and were attracted by KCl in chemotaxis assays. After massed training without an intertrial interval (ITI) or spaced training with 10-min ITI, by contrast, trained worms were attracted to nonanol. Memory induced by the massed training was extinguished within an hour, while that induced by the spaced training was retained for 24 h. Worms treated with anisomycin or actinomycin D failed to form the memory induced by the spaced training, whereas the memory induced by the massed training was not significantly affected by the mRNA and protein synthesis inhibitors. Furthermore, the memory induced by the massed training was sensitive to experimental disruption by cold-shock anesthesia. By definition, the memories induced by the massed and spaced training are classified as short-term and long-term memories, respectively. Hence this appetitive olfactory conditioning with nonanol and KCl as CS and US, respectively, shares many of the defining features of associative learning as exemplified by classical conditioning: stimulusand paring specificity, contiguity learning, and both shortas well as long-term retention. In support of this, C. elegans mutants defective in nmr-1 encoding an NMDA receptor subunit failed to form both of the short-term and long-term memory, while mutations in crh-1 encoding the CREB transcription factor affected only on the formation of the long-term memory. We are currently analyzing neural circuits responsible for this appetitive olfactory learning by using laser microsurgery. doi:10.1016/j.neures.2011.07.790 P2-p21 Short-term synaptic plasticity in the dentate gyrus of primates Ryoi Tamura 1 , Hiroshi Nishida 1,2, Satoshi Eifuku 1, Kaoru Nagao 1, Hiroaki Fushiki 2, Yukio Watanabe 2 1 Dept Integr Neurosci, Grad Sch Med & Pharmaceu Sci, Univ Toyama 2 Dept Otorhinolaryngol, Grad Sch Med & Pharmaceu Sci, Univ Toyama The hippocampus plays an important role in learning and memory. Synaptic plasticity in the hippocampus, short-term and long-term, is postulated to be a neural substrate of memory trace. Paired-pulse stimulation is a standard technique for evaluating a form of short-term synaptic plasticity in rodents. However, evidence is lacking for paired-pulse responses in the primate hippocampus. In the present study, we recorded paired-pulse responses in the dentate gyrus of monkeys while stimulating to the medial part of the perforant path at several inter-pulse intervals (IPIs) using low and high stimulus intensities. When the stimulus intensity was low, the first pulse produced early strong depression and late slight depression of field excitatory postsynaptic potentials (fEPSPs) generated by the second pulse, interposing no depression IPIs between these two depression phases. When the stimulus intensity was high, fEPSPs generated by the second pulse were depressed by the first pulse at all IPIs except for the longest one. Population spikes (PSs) generated by the second pulse were completely blocked or strongly depressed at shorter IPIs, while no depression or slight facilitation occurred at longer IPIs. Administration of diazepam slightly increased fEPSPs, while it decreased PSs produced by the first pulse. It also enhanced the facilitation of PSs produced by the second stimulation at longer IPIs. The present results, in comparison with previous studies using rodents, indicate that paired-pulse responses of fEPSPs in the monkey are basically similar to those of rodents, although paired-pulse responses of PSs in the monkey are more delayed than those in rodents and have a different sensitivity to diazepam. Research fund: KAKENHI(20500356). doi:10.1016/j.neures.2011.07.791 P2-q01 Neuroanatomical substrates involved in true and false memories for face as revealed by 3-T fMRI Tetsuya Iidaka 1 , Tokiko Harada 1, Jun Kawaguchi 2, Norihiro Sadato 3 1 Dept. of Psychiatry, Grad. Sch. of Med., Nagoya Univ. Nagoya, Japan 2 Dept. of Psychology, Nagoya University, Nagoya, Japan 3 NIPS, Okazaki, Japan In everyday situation we sometimes mistake an unknown person for a familiar person because of the resemblance of facial features. This kind of memory distortion, namely false memory, has been investigated by using words, pictures, and shapes; however, there is no study that used face pictures as memory items. The previous neuroimaging studies for false memory have demonstrated that there was similar activation in the medial temporal lobe between true and false memories; suggesting a common role of this structure in these memories. In the present fMRI study, we used a modified version of the Deese–Roediger–McDermott (DRM) paradigm and morphed face pictures to investigate neuroanatomical correlates of false memory for human face. Nineteen normal subjects (M/F, 8/11, mean age, 21 years) were scanned during the recognition task using “studied”, “non-studied but similar (lure)”, and “novel” face pictures. The behavioral data showed that the lure faces were erroneously recognized as the studied faces more often than the novel faces. We found that the amygdala activity was the greatest for correct and the least for incorrect responses and the activity related with false memory fell between them; indicating a role of amygdala in the detection of false |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neures.2011.07.791 |
| Volume Number | 71 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0168010211009746 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0168010211009746?dgcid=api_sd_search-api-endpoint |
| Journal | Neuroscience Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
