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Enantioselective functionalization of radical intermediates in redox catalysis: copper-catalyzed asymmetric oxytrifluoromethylation of alkenes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhu, Rong Ming Buchwald, Stephen L. |
| Copyright Year | 2013 |
| Abstract | A method for the efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism, in which a C–O bond is formed via the copper-mediated enantioselective trapping of a prochiral alkyl radical intermediate derived from the initial trifluoromethyl radical addition. |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/anie.201307790 |
| PubMed reference number | 24133010 |
| Journal | Medline |
| Volume Number | 52 |
| Issue Number | 48 |
| Alternate Webpage(s) | http://dspace.mit.edu/openaccess-disseminate/1721.1/94513 |
| Alternate Webpage(s) | http://dspace.mit.edu/bitstream/handle/1721.1/94513/Buchwald_Enantioselective.pdf;jsessionid=3CC81B84056EAD3C68C0C14F5A09BD25?sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.1002/anie.201307790 |
| Journal | Angewandte Chemie |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |