74. Dexamethasone activates Epstein Barr Virus lytic replication through immediate early BZLF1 gene expression

Content Provider	Semantic Scholar
Author	Kim, Seung-Jae Yang, Eric V. Chen, Min Marketon, Jeanette I. Webster Glaser, Ronald
Copyright Year	2008
Abstract	cancer diagnosis, which persisted after treatment. The purpose of this study was to determine whether adiposity contributed to IL-6 elevations in women diagnosed with breast cancer. Early stage breast cancer patients were evaluated prior to treatment and compared to women without breast cancer. Plasma IL-6, PBMC production of IL-6 and body mass index (BMI) were measured. Fifty-one percent of women with breast cancer and 58% of women without breast cancer were overweight (BMI >25 kg/m); while 23% of women with breast cancer versus 28% of women without breast cancer met obesity criteria (BMI > 30 kg/m). Women with breast cancer had greater plasma IL-6 levels than women without breast cancer. When plasma IL-6 levels were stratified by BMI, both overweight and obese women with breast cancer had higher plasma IL-6 than women with breast cancer with lower BMI (<25 kg/m2). IL-6 production significantly correlated (r = 0.461; p < 0.01) with BMI in women with breast cancer but no correlation was found in women without breast cancer. Thus, adipose tissue likely contributes to IL-6 elevations in breast cancer patients. Given the potential of IL-6 to stimulate breast cancer cell proliferation, adipose-tissue-driven inflammatory pathways may negatively impact cancer prognosis.
File Format	PDF HTM / HTML
DOI	10.1016/j.bbi.2008.04.075
Volume Number	22
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0889159108001311
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0889159108001311?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.bbi.2008.04.075
Journal	Brain, Behavior, and Immunity
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article