NDLI: Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.

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Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.

Content Provider	Semantic Scholar
Author	Zhou, Zhongjun Wang, Jianming Cao, Renhai Morita, Hiroyuki Soininen, Raija Chan, K. M. Liu, Baohua Cao, Yihai Tryggvason, K.
Copyright Year	2004
Abstract	Perlecan, a modular proteoglycan carrying primary heparan sulfate (HS) side chains, is a major component of blood vessel basement membranes. It sequesters growth factors such as fibroblast growth factor 2 (FGF-2) and regulates the ligand-receptor interactions on the cell surface, and thus it has been implicated in the control of angiogenesis. Both stimulatory and inhibitory effects of perlecan on FGF-2 signaling have been reported. To understand the in vivo function of HS carried by perlecan, the perlecan gene heparan sulfate proteoglycan 2 (Hspg2) was mutated in mouse by gene targeting. The HS at the NH(2) terminus of perlecan was removed while the core protein remained intact. Perlecan HS-deficient (Hspg2(Delta3/Delta3)) mice survived embryonic development and were apparently healthy as adults. However, mutant mice exhibited significantly delayed wound healing, retarded FGF-2-induced tumor growth, and defective angiogenesis. In the mouse corneal angiogenesis model, FGF-2-induced neovascularization was significantly impaired in Hspg2(Delta3/Delta3) mutant mice. Our results suggest that HS in perlecan positively regulates the angiogenesis in vivo.
Starting Page	499
Ending Page	501
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/64/14/4699.full.pdf
Alternate Webpage(s)	http://www.biochem.hku.hk/research/zzhou/zhoupdf/perlecan.pdf
Alternate Webpage(s)	http://www.sbms.hku.hk//research/zzhou/zhoupdf/perlecan.pdf
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/64/14/4699.full.pdf
PubMed reference number	15256433v1
Volume Number	64
Issue Number	14
Journal	Cancer research
Language	English
Access Restriction	Open
Subject Keyword	Basement membrane Corneal Neovascularization Embryonic Development Fibroblast Growth Factor Gene Targeting HSPG2 gene Heparitin Sulfate Impaired wound healing Ligands Neoplasms Pathologic Neovascularization Proteoglycan Recombinant Fibroblast Growth Factor-2 cellular targeting
Content Type	Text
Resource Type	Article

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