NDLI: Genepleio Software for Effective Estimation of Gene Pleiotropy from Protein Sequences

Content Provider	Semantic Scholar
Author	Chen, Wenhai Chen, Dandan Zhao, Ming Zou, Yangyun Zeng, Yanwu
Copyright Year	2015
Abstract	Though pleiotropy, which refers to the phenomenon of a gene affecting multiple traits, has long played a central role in genetics, development, and evolution, estimation of the number of pleiotropy components remains a hard mission to accomplish. In this paper, we report a newly developed software package, Genepleio, to estimate the effective gene pleiotropy from phylogenetic analysis of protein sequences. Since this estimate can be interpreted as the minimum pleiotropy of a gene, it is used to play a role of reference for many empirical pleiotropy measures. This work would facilitate our understanding of how gene pleiotropy affects the pattern of genotype-phenotype map and the consequence of organismal evolution.
File Format	PDF HTM / HTML
DOI	10.1155/2015/269150
PubMed reference number	25629041
Journal	Medline
Volume Number	2015
Alternate Webpage(s)	http://downloads.hindawi.com/journals/bmri/2015/269150.pdf
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/d5/6a/BMRI2015-269150.PMC4299487.pdf
Alternate Webpage(s)	https://doi.org/10.1155/2015%2F269150
Journal	BioMed research international
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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