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Efectos del extracto de semillas de uva sobre la cistopatia diabética inducida por estreptozotocina en ratas
| Content Provider | Semantic Scholar |
|---|---|
| Author | Arruzazabala, María De Lourdes Ravelo, Yazmín Carbajal, Daisy Molina, Vivian Más, Rosa |
| Copyright Year | 2010 |
| Abstract | Streptozotocin (STZ)-induced diabetes in rats results from a subtotal necrosis of the pancreatic islets, produc- ing hyperglycemia, hypoinsulinemia, reduction of bodyweight gain and increase of bladder weight, accompanied by the hypercontractility to carbachol due to the over-expression of the M 2 and M 3 mRNAs-muscarinic receptors of the detrusor muscle and urothelium. Grape seed extract (GSE), rich in flavonoids, exerts antioxidant and neuroprotective effects on experimental models. Hence, this study researched whether the treatment with GSE ameliorates the STZ-induced cystopa- thy in rats. Animals were distributed into three groups: a non-diabetic negative control group and two others treated with STZ (50 mg/kg, intraperitoneal). Four weeks later, both the negative control and one of the STZ-treated groups (positive control) received orally (p.o.) the vehicle, while the third one received GSE (200 mg/(kg · d), p.o.) during four weeks. At the end of this period body weight, serum levels of glucose and creatinine were determined. Bladder functional activity was researched using carbachol (10 -7 |
| Starting Page | 99 |
| Ending Page | 102 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Volume Number | 41 |
| Alternate Webpage(s) | http://revista.cnic.edu.cu/revistaCB/sites/default/files/articulos/Articulo%20No%202%20B02-09.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
