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A versatile catalyst for Heck reactions of aryl chlorides and aryl bromides under mild conditions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Littke, Adam F. Fu, Gregory C. |
| Copyright Year | 2001 |
| Abstract | In the presence of Cy2NMe, Pd/P(t-Bu)3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides. A sterically and electronically diverse array of aryl bromides, as well as activated aryl chlorides, couple with a range of mono- and disubstituted olefins at room temperature, furnishing the arylated product with high E/Z stereoselection. The corresponding reactions of a broad spectrum of electron-neutral and electron-rich aryl chlorides proceed at elevated temperature, also with high selectivity. In terms of scope and mildness, Pd/P(t-Bu)3/Cy2NMe represents an advance over previously reported catalysts for these Heck coupling processes. |
| Starting Page | 6989 |
| Ending Page | 7000 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/ja010988c |
| PubMed reference number | 11459477 |
| Journal | Medline |
| Volume Number | 123 |
| Issue Number | 29 |
| Alternate Webpage(s) | http://www.chem.ccu.edu.tw/~joyce/referance/gump/IL/J.%20Am.%20Chem.%20Soc.%202001,%20123,%206989.pdf?origin=publication_detail |
| Journal | Journal of the American Chemical Society |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
