NDLI: In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants.

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In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants.

Content Provider	Semantic Scholar
Author	Koudouvo, Koffi Karou, Simplice Damintoti Ilboudo, Denise P. Kokou, Kouami Essien, K. Aklikokou, K. Souza, Comlan De Simpore, Jacques Gbéassor, Mensavi
Copyright Year	2011
Abstract	OBJECTIVE To investigate the antimalarial effect of a few plants in Togo folk medicine. METHODS After ethnobotanical survey, Opilia celtidifolia, Pavetta corymbosa (P. corymbosa) and Tamarindus indica (T. indica) were selected for screening. In vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Plasmodium falciparum using the semi microtest. RESULTS Different IC(50) values of the extracts ranged from 2.042 to 100.000 μg/mL. According to the results, the methanol extract of aerial part of P. corymbosa followed by aqueous extract of fruit of T. indica were the most active (IC(50) of 2.042 and 4.786 μg/mL, respectively). Qualitative test revealed the presence of alkaloids in the leaves of P. corymbosa that may be responsible for the activity of the plant. CONCLUSIONS Our study provides scientific evidence for usage of plant in the folk medicine, and further studies are needed for identification and purification of the active principles.
File Format	PDF HTM / HTML
DOI	10.1016/S1995-7645(11)60052-7
PubMed reference number	21771436
Journal	Medline
Volume Number	4
Issue Number	2
Alternate Webpage(s)	http://www.labiogene.org/IMG/pdf/plasmodium_koudouvo.pdf
Alternate Webpage(s)	https://doi.org/10.1016/S1995-7645%2811%2960052-7
Journal	Asian Pacific journal of tropical medicine
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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