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Crosstalk between GH/IGF-I axis and steroid hormones (progesterone, 17β-estradiol) in canine mammary tumours
| Content Provider | Semantic Scholar |
|---|---|
| Author | Queiroga, Felisbina L. Pérez-Alenza, Maria Dolores Silvan, G. R. Peña, Laura Illera, Juan Carlos |
| Copyright Year | 2008 |
| Abstract | Growth hormone (GH), insulin-like growth factor I (IGF-I), progesterone (P4) and 17beta-estradiol (17-E2) concentrations have been studied in 84 mammary tumours (44 dysplasias and benign tumours and 40 malignant neoplasias) from 33 female dogs. Thirteen normal mammary glands from 80 healthy female dogs were also analysed as controls. GH concentrations were determined in mammary homogenates by radio-immunoassay. IGF-I, P4 and 17-E2 tissue levels were determined by enzyme-immunoassay (EIA) techniques. The potential correlations between GH/IGF-I concentrations and P4 and 17-E2 mammary tissue levels were investigated. Tissue GH (p<0.01) and IGF-I concentrations (p<0.01) were significantly higher in malignant tumours than in benign neoplasms. Likewise, malignant tumours were the mammary lesions that displayed the highest P4 and 17-E2 tissue levels. Strong correlations between GH/IGF-I (n=84; r=0.436; p<0.001), P4/GH (n=84; r=0.562; p<0.001) and 17-E2/IGF-I (n=84; r=0.638; p<0.001) were observed in tumoral tissue homogenates. Our study provides evidence that P4 might increase autocrine GH production which might directly stimulate local or systemic IGF-I secretion. Additionally, the IGF-I effect might be influenced by local levels of 17-E2. These results suggest that all these hormones and factors might act as local growth factors stimulating the development and/or maintenance of canine mammary tumours in an autocrine/paracrine manner. |
| Starting Page | 76 |
| Ending Page | 82 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jsbmb.2008.02.005 |
| PubMed reference number | 18367392 |
| Journal | Medline |
| Volume Number | 110 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0960076008000356 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0960076008000356?dgcid=api_sd_search-api-endpoint |
| Journal | The Journal of Steroid Biochemistry and Molecular Biology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
