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A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outstide Africa.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Alonso, Santos Armour, John A. L. |
| Copyright Year | 2001 |
| Abstract | We have sequenced a highly polymorphic subterminal noncoding region from human chromosome 16p13.3 flanking the 5' end of the hypervariable minisatellite MS205, in 100 chromosomes sampled from different African and Euroasiatic populations. Coalescence analysis indicates that the time to the most recent common ancestor (approximately 1 million years) predates the appearance of anatomically modern human forms. The root of the network describing this variability lies in Africa. African populations show a greater level of diversity and deeper branches. Most Euroasiatic variability seems to have been generated after a recent out-of-Africa range expansion. A history of population growth is the most likely scenario for the Euroasiatic populations. This pattern of nuclear variability can be reconciled with inferences based on mitochondrial DNA. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.98.3.864 |
| PubMed reference number | 11158547 |
| Journal | Medline |
| Volume Number | 98 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://www.pnas.org/content/98/3/864.full.pdf |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
