NDLI: Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.

Please wait, while we are loading the content...

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.

Content Provider	Semantic Scholar
Author	Grode, Leander Seiler, Peter Baumann, Sven Heß, Jürgen Brinkmann, Volker Eddine, Ali Nasser Mann, Peggy L. Goosmann, Christian Bandermann, Silke Smith, Debbie Bancroft, Gregory J. Reyrat, Jean-Marc Soolingen, Dick Van Raupach, Bärbel Kaufmann, Stefan H. E.
Copyright Year	2005
Abstract	The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improve protection against Mycobacterium tuberculosis. Following aerosol challenge, the Hly-secreting recombinant BCG (hly+ rBCG) vaccine was shown to protect significantly better against aerosol infection with M. tuberculosis than did the parental BCG strain. The isogenic, urease C-deficient hly+ rBCG (DeltaureC hly+ rBCG) vaccine, providing an intraphagosomal pH closer to the acidic pH optimum for Hly activity, exhibited still higher vaccine efficacy than parental BCG. DeltaureC hly+ rBCG also induced profound protection against a member of the M. tuberculosis Beijing/W genotype family while parental BCG failed to do so consistently. Hly not only promoted antigen translocation into the cytoplasm but also apoptosis of infected macrophages. We concluded that superior vaccine efficacy of DeltaureC hly+ rBCG as compared with parental BCG is primarily based on improved cross-priming, which causes enhanced T cell-mediated immunity.
File Format	PDF HTM / HTML
DOI	10.1172/JCI24617
PubMed reference number	16110326
Journal	Medline
Volume Number	115
Issue Number	9
Alternate Webpage(s)	http://www.jci.org/articles/view/24617/version/1/pdf/render
Alternate Webpage(s)	https://dm5migu4zj3pb.cloudfront.net/manuscripts/24000/24617/cache/24617.1-20150227135649-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf
Alternate Webpage(s)	https://www.jci.org/articles/view/24617/pdf/render
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/24000/24617/JCI0524617.pdf
Alternate Webpage(s)	https://doi.org/10.1172/JCI24617
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in